Interferon Induction by Viruses. Sindbis Virus: Defective-interfering Particles Temperature-sensitive for Interferon Induction
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چکیده
منابع مشابه
Interferon Induction by Viruses
Interferons are proteins of cellular origin capable of conferring virus resistance to vertebrate cells. Most cells do not produce interferons except in response to proper stimulation. Clearly, the stimulation of interferon production encompasses two phenomena. When stimulated, some cell systems produce their interferons by synthesizing new proteins. Other cell systems do not require the synthes...
متن کاملMolecular Aspects of Interferon Induction by Viruses
Virus-induced interferon formation depends on the presence within the cell of a viral ribonucleic acid. This RNA may either be double stranded or, in certain cases, single stranded. The double-stranded RNA can be derived from a virus, such as reovirus, which contains this type of RNA, or it may be synthesized within the cell using viral single-stranded RNA as a template. Single-stranded RNA mus...
متن کاملInterferon induction by adenoviruses.
All human, simian, bovine and avian adenovirus types tested so far and the canine hepatitis virus induce interferon production in chick cells. This finding indicated this property to be characteristic for viruses belonging to the adenovirus group. Trypsin treatment, which had no effect upon the infectivity, diminished or eliminated the interferon-inducing abilities of crude adenoviruses, and th...
متن کاملInterferon Induction by RNA Viruses and Antagonism by Viral Pathogens
Interferons are a group of small proteins that play key roles in host antiviral innate immunity. Their induction mainly relies on host pattern recognition receptors (PRR). Host PRR for RNA viruses include Toll-like receptors (TLR) and retinoic acid-inducible gene I (RIG-I) like receptors (RLR). Activation of both TLR and RLR pathways can eventually lead to the secretion of type I IFNs, which ca...
متن کاملHeterocellular induction of interferon by negative-sense RNA viruses
The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus a...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1980
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-48-2-391